Biomolecular Free Radical Toxicity

Split into three sections, the book covers: * macromolecular mechanisms of injury and the role of antioxidants; * gene expression and cell mediated mechanisms of toxicity expression; and, * human and environmental health effects.

Author: Helen Wiseman

Publisher: Wiley

ISBN: 9780471490760

Category: Science

Page: 260

View: 312

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers: * macromolecular mechanisms of injury and the role of antioxidants; * gene expression and cell mediated mechanisms of toxicity expression; and, * human and environmental health effects. Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.

Journal of the Institute of Brewing

2. Wiseman , A. ( ed ) , Handbook of Enzyme Biotechnology : 3rd Edition , Ellis
Horwood , ( Prentice Hall ) , Hemel Hempstead , England , 1995 . 3. Wiseman , H.
, Goldfarb , P. , Ridway , T. and Wiseman , A. , Biomolecular Free Radical Toxicity
 ...

Author: Institute of Brewing (Great Britain).

Publisher:

ISBN:

Category: Brewing

Page:

View: 903


Food Nutrition and Chemical Toxicity

Free Radical Research Communications 7 , 121 – 128 . Arduini , A . ... Free
Radical Biology and Medicine 9 , 511 - 513 . ... and therapeutic chelators on the
generation of reactive oxygen species and the inducement of biomolecular
damage .

Author: Dennis V. Parke

Publisher: Smith Gordon & Company Limited

ISBN:

Category: Health & Fitness

Page: 451

View: 238


Reactive Oxidant Generation by Nanoparticulate Zero valent Iron

Contaminant Oxidation and Toxicity Christina Renee Keenan ... Free Radical
Biology and Medicine 2004 , 36 , 850857 . ... Qian , S. Y .; Buettner , G. R. , Iron
and dioxygen chemistry is an important route to initiation of biological free radical
oxidations : An electron paramagnetic resonance ... Welch , K. D .; Davis , T. Z .;
Van Eden , M. E .; Aust , S. D. , Deleterious ironmediated oxidation of
biomolecules .

Author: Christina Renee Keenan

Publisher:

ISBN:

Category:

Page: 336

View: 122


Aging

Formation of free radicals in arthritis involves various sources which include the
electron transport chain in mitochondria, purine ... iron and copper ions, which
may further amplify free radical toxicity.12 Other Possible Sources Some other
possible sources of free radicals ... of an increase in ROS production
characterized by biomolecular deterioration and an alteration in the antioxidant
defense system.

Author: Victor R. Preedy

Publisher: Academic Press

ISBN: 0124055230

Category: Technology & Engineering

Page: 316

View: 635

Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Patty s Industrial Hygiene and Toxicology

The molecular basis for ozone toxicity has been reviewed recently by Mustafa ,
who categorizes the various reported effects as oxidation of functional groups of
biomolecules , production of free radicals and reactive intermediates , initiation of
 ...

Author: Frank Arthur Patty

Publisher:

ISBN:

Category: Industrial hygiene

Page:

View: 676


The Skeptical Inquirer

For a good introduction to this topic see Free Radicals in losis , arthritis , heart
disease , and stroke are cured by thera ... Free radical oxidants owe their
toxAnother interesting and characteristic aspect of the oxygen icity to their ability
to react with biomolecules ( e.g. , lipids ... Free Radical Oxidants Oxygen is Toxic
Hydrogen peroxide ( H2O2 ) is a familiar component of most home medicine
chests .

Author:

Publisher:

ISBN:

Category: Electronic journals

Page:

View: 594


Phytonutrients

In: Biomolecular Free Radical Toxicity: Causes and Prevention (eds H. Wiseman,
P. Goldfarb, T.J. Ridgway and A. Wiseman), pp. 170–208. Chichester: John Wiley
& Sons Ltd. Wiseman, H. (2000b) The therapeutic potential of phytoestrogens.

Author: Andrew Salter

Publisher: John Wiley & Sons

ISBN: 1118240928

Category: Technology & Engineering

Page: 312

View: 873

In many Western diets, the role of plants has been reduced in favour of more animal-based products and this is now being cited more widely as being the cause of increases in the incidence of diseases such as cancer and cardiovascular disease. This important book covers the biochemistry and nutritional importance of a wide range of phytonutrients, including all the major macronutrients as well as the micronutrients and 'non-essential' nutrients. Phytonutrients is divided into three parts. The first deals with the role of plants in the human diet. Part II, representing the major part of the book covers in turn each of the major phytonutrient groups. Chapters include: non-lipid micronutrients, lipids and steroids, carotenoids, phenolics, vitamins C, E, folate/vitamin B12, phytoestrogens, other phytonutrients and minerals, and anti-nutritional factors. The final part of the book covers the methods used to manipulate levels of phytonutrients in the diet, such as fortification, supplementation and the use of genetically modified plants. Phytonutrients is an essential purchase for nutritionists, food scientists and plant biochemists, particularly those dealing with nutrients from plants, and their use in the human diet.

High Throughput Screening Methods in Toxicity Testing

An electron or hydrogen transfer could lead to the formation of free radical
species (type I photochemical reaction), producing a direct attack on the
biomolecules or, in the presence of oxygen, evolving toward secondary free
radicals such as ...

Author: Pablo Steinberg

Publisher: John Wiley & Sons

ISBN: 1118538242

Category: Science

Page: 570

View: 764

Explores the benefits and limitations of the latesthigh-throughput screening methods With its expert coverage of high-throughput in vitroscreening methods for toxicity testing, this book makes it possiblefor researchers to accelerate and streamline the evaluation andrisk assessment of chemicals and drugs for toxicity. Moreover, itenables them to comply with the latest standards set forth by theU.S. National Research Council's "Toxicity Testing in the 21stCentury: A Vision and Strategy" and the E.U.'s REACH legislation.Readers will discover a variety of state-of-the-science,high-throughput screening methods presented by a group of leadingauthorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing isdivided into five parts: General aspects, including predicting the toxicity potential ofchemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, andhaematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailedinformation about data generation, data analysis, and applicationsin risk assessment. The authors not only enumerate the advantagesof each high-throughput method over comparable conventionalmethods, but also point out the high-throughput method'slimitations and potential pitfalls. In addition, the authorsdescribe current research efforts to make high-throughput toxicityscreening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures andillustrations to help them understand and perform the latesthigh-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers whoneed to implement high-throughput screening methods for toxicitytesting in their laboratories as well as for researchers who needto evaluate the data generated by these methods.

Aging

The two-hit hypoth- esis postulates that the aging of biomolecules in a living
system, caused by various biologic and environmental ... Denham Harman's free
radical theory of aging suggests that the chronic production of endogenous free
radicals and subse- quent ... and. free. radicals. Today's concept of "oxygen
toxicity" is not restricted only to some diseases: it is now receiving much attention
and aims ...

Author: Victor R. Preedy

Publisher: Academic Press

ISBN: 0128188111

Category: Technology & Engineering

Page: 398

View: 182

Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients. Compares information related to mitochondrial oxidative stress in one disease to diet-related strategies in other unrelated diseases Provides an understanding of cell signalling leading to new suggestions of preventative or therapeutic strategies Includes a new section dedicated to animal models of aging

Encyclopedia of Human Biology Fl Im

Defenses against Free Radical Toxicity V. Diseases Associated with Free
Radical Injury VI . Summary A ... When produced in excess , they can be lethal to
the host owing to their ability to modify a spectrum of biomolecules . GLOSSARY
1.

Author: Renato Dulbecco

Publisher:

ISBN: 9780122269745

Category: Biology

Page: 807

View: 528


Acta physiologica scandinavica supplementum

An approach to free radicals in medicine and biology ROLANDO F. DEL
MAESTRO aboratory for Experimental Brain Research ... the environment has
necessitated the development of a group of mechanisms to deal with the toxic
free radical byproducts of oxidative metabolism . ... The elucidation of the
relationship of individual free radical species to the biomolecular and tissue
injury which occurs during ...

Author:

Publisher:

ISBN:

Category:

Page:

View: 917


Renal Response to Isotonic Volume Expansion in the Developing Rat

An approach to free radicals in medicine and biology ROLANDO F. DEL
MAESTRO Laboratory for Experimental Brain Research ... into the environment
has necessitated the development of a group of mechanisms to deal with the
toxic free radical byproducts of oxidative metabolism . ... The elucidation of the
relationship of individual free radical species to the biomolecular and tissue
injury which occurs ...

Author: Göran Elinder

Publisher:

ISBN:

Category: Kidney function tests

Page: 24

View: 729


Alcohol Toxicity and Free Radical Mechanisms

Free radicals are molecules or molecular fragments containing an unpaired
electron ( s ) , this normally gives the free ... Thus , free radicals such as hydroxyl (
HO • ) interact in solution more or less unspecifically , with most biomolecules in ...

Author: European Society for Biomedical Research on Alcoholism. Congress

Publisher: Pergamon

ISBN:

Category: Alcohol

Page: 371

View: 200


Biochemistry and Cell Biology

Toxic free radicals can be produced by many reactions required for the
maintenance of normal metabolism and the production of energy in the cell . The
reactivity of both primary and secondary radicals with biomolecules and in whole
tissue ...

Author:

Publisher:

ISBN:

Category: Biochemistry

Page:

View: 408


Cytobios

Oxygen toxicity Oxygen is a double-edged sword: it is required for respiration, yet
in its free-radical form, it interacts and degrades other biomolecules. The toxicity
of inhaled oxygen increases logarithmically with its atmospheric concentration.

Author:

Publisher:

ISBN:

Category: Cells

Page:

View: 228


The Smallest Biomolecules Diatomics and their Interactions with Heme Proteins

CONCLUSIONS AND PROSPECTIVE With greater knowledge of NO toxicity,
signaling, and the many sources of NO ... The bound −O2 • may be particularly
suited to terminating free radicals, or generating radicals [302], with a similar ...

Author: Abhik Ghosh

Publisher: Elsevier

ISBN: 9780080556321

Category: Science

Page: 614

View: 994

This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists. Extremely distinguished list of authors Multidisciplinary character – equally suitable for chemists and biochemists Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.

Responses of Plant Metabolism to Air Pollution and Global Change

The other potentially toxic metabolite of nitrate assimilation pathway is
ammonium , which reportedly accumulates in the ... Free radical generation and
their oxidizing effects on important biomolecules including nucleic acids and
proteins are ...

Author: Luit J. De Kok

Publisher:

ISBN:

Category: Global environmental change

Page: 519

View: 709


Chemtracts

Free Radicals and Oxidation Phenomena in Biological Systems Marcel
Roberfroid and Pedro Buc Calderon , Université ... on the interactions and
biological implications of transition - metal activation of oxygen , mechanisms of
biomolecule damage , environmental ... chemists to the basic principles of
toxicology and to introduce biologists to the fundamental reaction chemistry
responsible for toxicity .

Author:

Publisher:

ISBN:

Category: Biochemistry

Page:

View: 705

Consists of condensations of journal articles with commentaries and some original articles.

Drug Toxicity

ensuing process is converted to a relatively stable nitroxyl radical having a
characteristic triplet ESR spectrum . ... procedures that result in scavenging or
trapping the reactive free radical intermediates . ... the trichloromethyl radical is
chemically very reactive , it interacts readily with a variety of neighbouring
biomolecules ...

Author: John W. Gorrod

Publisher: Taylor & Francis Group

ISBN:

Category: Drugs

Page: 326

View: 910