From Molecular to Modular Tumor Therapy

Albrecht Reichle Abstract How can get structured therapies in metastatic cancer a source for detecting tumor-associated systems-biological processes as adjustable sizes available for biomodulatory therapies?

Author: Albrecht Reichle

Publisher: Springer Science & Business Media

ISBN: 9048195314

Category: Medical

Page: 568

View: 351

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on different sciences, in addition to other strategies.

Evolution adjusted Tumor Pathophysiology

24. 25. 26. 27. 28. 29. 30. Reichle A, Hildebrandt GC (2010) From molecular to modular, from theme-dependent to evolution-adjusted tumor therapy. In: From molecular to modular tumor therapy: The tumor microenvironment, vol 3, part 9.

Author: Albrecht Reichle

Publisher: Springer Science & Business Media

ISBN: 9400768664

Category: Medical

Page: 453

View: 677

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.

From Molecular to Modular Tumor Therapy

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease.

Author: Albrecht Reichle

Publisher: Springer

ISBN: 9789048195329

Category: Medical

Page: 568

View: 627

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on different sciences, in addition to other strategies.

PPARs in Cellular and Whole Body Energy Metabolism

Liu, D.; Mai, K.; Zhang, Y.; Xu, W.; Ai, Q. Tumour necrosis factor-α inhibits hepatic lipid deposition through ... In From Molecular to Modular Tumor Therapy; Reichle, A., Ed.; Springer Netherlands: Dordrecht, The Netherlands, 2010; pp.

Author: Walter Wahli

Publisher: MDPI

ISBN: 3038974617

Category:

Page: 583

View: 800

This book is a printed edition of the Special Issue "PPARs in Cellular and Whole Body Energy Metabolism" that was published in IJMS

Mathematical Modelling of Molecular Networks in Cancer Cells Using Modular Response Analysis

Cancer emerges from the body's own cells that via mutations have become semi-autonomous with often fatal consequences for the host.

Author: Bertram Klinger

Publisher:

ISBN: 9783832542993

Category:

Page: 177

View: 391

Cancer emerges from the body's own cells that via mutations have become semi-autonomous with often fatal consequences for the host. To date, 25 % of all death cases in Germany can be attributed to cancer. One reason behind the inability to confine tumours with current therapy approaches resides in the lack of comprehension of the complex molecular changes that occur during malignant transformation. In order to thoroughly study molecular networks in cancer, the mathematical modelling technique Modular Response Analysis was extended for application to various tasks such as network reconstruction, feedback analysis, and hypothesis testing. These analyses enabled to extend the understanding of molecular interactions and to identify a potent combinatorial treatment strategy for a mutation type of cancer previously assumed to be undruggable.

Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

Therefore, the absence or reduction of FN in tumor cells may reduce the adhesion be‐tween tumor cells and matrix ... Twelve type I modules make up the amino-terminal and carboxy-terminal region of the molecule, and are involved mainly ...

Author: Terry Lichtor

Publisher: BoD – Books on Demand

ISBN: 9535109898

Category: Medical

Page: 650

View: 753

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Protein Modules in Cellular Signalling

Standard cancer therapy with ionising radiation or cytostatic drugs involves the administration of an agent that ... These would utilise tumor - specific molecular targets and lead to restoration of the normal apoptotic response .

Author: Ludwig Heilmeyer

Publisher: IOS Press

ISBN: 9781586031800

Category: Science

Page: 416

View: 567

Dynamic stability of cells is a function of co-ordination and counterbalance between intracellular signalling events. Therefore, the knowledge of those molecules which form signalling cascades or signalling modules is of prime importance in understanding living processes. Signalling proteins, the component members of different cascades, are the focus of intense interest. Protein phosphorylation dephosphorylation is the prevalent mechanism by which signalling molecules transduce their signals.

Supramolecular Assembly Based Functional Nanostructures for Biomedical Applications

Nanotechnology has been widely used to enhance the therapeutic potency and safety of current cancer immunotherapy ... Moreover, supramolecular-assembled nanostructures make it easier to control multiple modules with the relatively weak ...

Author: Tianjiao Ji

Publisher: Frontiers Media SA

ISBN: 2889665208

Category: Science

Page:

View: 330


Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg

This can severely limit the stability and solubility of scFv modules. Bispecific antibodies can be generated from two distinct heavy chains. In order to circumvent mispairing of VH–VL domains, a common “fixed” light chain is used that ...

Author: Leonor Kremer

Publisher: Frontiers Media SA

ISBN: 2889454622

Category:

Page:

View: 682

The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or new combinations. In this e-book we present relevant research depicting the current efforts in the field.

Emerging Molecular Signaling Pathways and Therapeutic Targets for Genitourinary Cancer Metastasis

FIGURE 7 | WGCNA was performed to identify modules associated with the clinical traits of KIRC. ... (D) Heatmaps of the correlation between Eigengene of mRNAs and clinical traits of KIRC cancer were displayed. Each module with different ...

Author: Jinbo Chen

Publisher: Frontiers Media SA

ISBN: 2889749908

Category: Medical

Page:

View: 936