A note on “radical treatment” is warranted. The word radical was used in the early
part of the twentieth century to distinguish surgical intervention from the “
conservative,” nonsurgical, treatment of illness and disease. Thus, “radical”
appears in ...
Author: Richard Leblanc
Publisher: McGill-Queen's Press - MQUP
Wilder Penfield (1891–1976) is famous for his contributions to the understanding of epilepsy and for his discoveries of the relationship between the structure and function of the human brain. His operations, which involved stimulating the cerebral cortex of awake patients with a fine electrode, assured the complete removal of lesions that caused epilepsy. Less widely known is his use of the same technique to localize the interpretation of language, the recording of memories, and the ability to interpret the present in light of past experience. Radical Treatment follows the evolution of Penfield's thinking from his description of brain scars at the beginning of his career to his last thoughts on the human condition. Through a review of his clinical charts, intraoperative sketches, manuscript notes, and other archival material held at the Montreal Neurological Institute and Hospital, this book presents a fascinating narrative of the development of Penfield's career and the processes that led to each of his great discoveries. Richard Leblanc vividly conveys the collaborative nature of Penfield's work at the Royal Victoria Hospital and at the MNI, which led to his greatest discoveries. Revealing the duality of a life in science, Leblanc shows that while Penfield was instrumental in establishing the localization of specific functions to distinct regions of the brain, he concurrently stressed the integrative action of the nervous system. Written by the leading authority on the history of Penfield's Montreal Neurological Institute, Radical Treatment is an insightful account of the scientific accomplishments of one of the twentieth century's most influential neuroscientists.
He worried that maybe this radical treatment plan of his was a little too radical.
Maybe Wickham had been right. Maybe he wasn't cut out for this tough- guy stuff.
Just as his depression was about to overwhelm him, Peter saw a tiny dust cloud ...
Author: Dale E. Wagman
Michael Manning thought he was doing everything right. He worked hard to afford a nice home in a nice community and to send his children to good schools. When his bright and athletic son turns to drug and alcohol abuse, he is devastated. After conventional treatment programs fail, and his family is torn apart, Michael embarks on a radical course of treatment. Kidnapping his son, he removes him from the environment that has caused his problems and forces him to learn to survive in the wilderness...or die.
Conventional staging procedures may conclude that a patient is eligible for
radical radiation therapy but in a significant ... and colleagues reported on 8 of 26
patients (31%) with NSCLC who were upstaged by PET when imaged in
Author: Arnold C. Paulino
Publisher: Elsevier Health Sciences
Here is an exciting new guide to the use of PET-CT imaging in radiotherapy. You’ll get practical, useful information for utilizing this novel imaging technique—from different methods for contouring biological target volumes in various anatomic regions to how different experts use this imaging in targeted treatment. This thorough text helps you make concise, accurate treatment choices based on current evidence and expert authority. The result is an essential tool for everyone on the radiotherapy treatment team in the era of image-guided radiotherapy. Helps familiarize you with the basics of PET imaging in nuclear medicine. Covers the use of PET-CT with radiotherapy treatment planning, offering practical guidance in how different experts use this relatively new technology. Highlights contrast using full-color images, clearly indicating target volumes and different radiation dosages. Outlines the advantages and disadvantages of different techniques in contouring PET-CT target volumes for radiotherapy. Features case illustrations in using PET-CT in radiotherapy treatment planning for different tumor sites.
Author: Attilio CATTERINA
The clinical utility of such scans may be limited to providing reassurance to patients with a negative scan, given the high negative predictive value in our series.
Author: Yee Kei To
BackgroundImaging follow up after radical treatment for cervical cancer with chemoradiotherapy and brachytherapy may be warranted if asymptomatic persistent or recurrent disease can be detected such that salvage treatment can be undertaken with curative intent. Since 2013, in Aberdeen Royal Infirmary, follow up MRI at 3 months and/or PET-CT at 9 months post-treatment have been organised for patients in whom salvage pelvic exenteration would be considered in the event of central recurrence.MethodologyAll patients with cervical cancer treated non-surgically with curative intent at Aberdeen Royal Infirmary were identified from the radiotherapy database, between 2012 and 2018. Patients who had undergone a 3 month MRI and/or a 9 month CT-PET scan were identified and the results of these were collated, with the subsequent impact on patient management identified from the electronic patient record.ResultsTwenty-nine and 32 patients underwent a post-treatment MRI and PET-CT scanning respectively. Following MRI, 16 patients had no residual disease (NRD) and have not relapsed to date, 5 had NRD but subsequently relapsed systemically, 5 had residual or new disease unsuitable for salvage, and 3 had potentially salvageable disease (1 undergoing exenteration but subsequently relapsing, 1 progressing prior to exenteration and 1 who did not pursue salvage).Following PET-CT, 24 patients had NRD and have not relapsed to date, 7 had unsalvageable metastatic or pelvic disease and 1 had persistent pelvic side wall disease that was considered unsalvageable at the time but might now have been considered for salvage ablative radiotherapy.ConclusionIn our cohort, post treatment MRI at 3 months and/or PET-CT at 9 months have not led to any additional patients being cured of their cancer. The clinical utility of such scans may be limited to providing reassurance to patients with a negative scan, given the high negative predictive value in our series.
The techniques for local ablation have been listed and briefly described,
including external irradiation alone (Bagshaw'), interstitial alone or with radical
prostatectomy (Flocks"), radical prostatectomy, both perineal and retropubic,
Author: J.E. Castro
Publisher: Springer Science & Business Media
In 1963 Professor Huggins! wrote "more than one half of the male population over the age of 50 suffer from benign tumors known as prostatic hypertrophy. Often an enlarged prostate is the only difficulty to cloud an otherwise tranquil old age". This statement emphasizes two important features of benign prostatic hypertrophy (BPH); the frequency with which it occurs and its association with increasing age. The true incidence is difficult to determine as most data relate to selected groups of patients; moreover, the diagnostic criteria of prostatic hypertrophy are not clearly defined. Normality merges imperceptibly into abnormality, for even in men who are clinically normal, rates of urinary flow decrease with 2 increasing age . Despite these inaccuracies, incidence figures show the magnitude of the problem; Flocks (1963) 3 reported that 65% of American men over 60 years suffer from it and in a selected group of Danish men 43% had symptoms of the 4 disease ; similar figures are reported for the U ni ted Kingdom 5. At present most patients with BPH, who need treatment, undergo surgical prostatectomy which may be considered the usual treatment. The frequency of the disease alone, creates certain problems, for annually more than 30000 men are admitted to hospital in the United States with this as a primary diagnosis and with an ageing population the figures can be expected to increase.
Insignificant prostate cancerin radical prostatectomy specimen: time trends and
preoperative prediction. Eur Urol 2003; 43:455–60. Klotz LH, NCIC Clinical Trial
Group. Active surveillance versus radical treatment for favorable risk localized ...
Author: Roger Kirby
Publisher: CRC Press
Radical prostatectomy involves the surgical removal of the entire prostate gland and the seminal vesicles. Recently the open operation has been challenged by laparoscopic and robotic techniques. However, making the transition to this new technology is not an easy option. Avoiding surgical complications such as incontinence and ensuring continued erectile function following the procedure requires good surgical technique by whatever means. The editors and their distinguished team of contributors from around the world offer the reader their guidance based on personal experience and best surgical practice. Radical Prostatectomy is required reading for all those performing radical prostatectomy by open, laparoscopic or robotic techniques.
age , excepting perhaps in a few cases , the radical treatment must not be
expected to render the use of a truss unnecessary . In considering the large
proportion of patients in which I have stated that the use of a truss after the radical
Author: Sir William Henry Bennett
Stefano Ciatto Keywords Before the prostate-specific antigen (PSA) era,
surveillance of asymptomatic patients after primary radical treatment for prostate
cancer was essentially based on digital rectal examination. When measurement
of the ...
Author: Frank E Johnson
Publisher: Springer Science & Business Media
Patient Surveillance After Cancer Treatment covers the history of cancer patient surveillance after curative-intent treatment, the rationale, the methodologies used in the past and at present, the methodologies that will probably emerge in the future, the costs of surveillance, the definitions of various terms used in the field, and how those who are interested in the topic can get more information about it from the internet. The secondary focus of the book is to publicize the need for well-designed, adequately powered randomized clinical trials comparing two (or more) surveillance strategies for each type of cancer. The audience includes all oncologists, cancer researchers, medical economists and policy makers in government and insurance companies, and finally, interested patients. This book is part of the Current Clinical Oncology series, which provides cutting-edge knowledge of cancer diagnosis, management, and treatment. World renowned experts share their insights in all the major fields of clinical oncology. From the fundamentals of pathophysiology to the latest developments in experimental and novel therapies, Current Clinical Oncology is an indispensable resource for today’s practicing oncologist.
Surgical operation of traditional treatment has been developing for over 100
years, radical treatment for 80 years and chemical treatment for 60 years. But
until now, the cancer is still rampant in the crowd, and the three treatments
produce little ...
Author: Xu Ze Xu Jie Bin Wu
Category: Health & Fitness
This book is the scientific summary of the author’s treatment experience on oncology surgery during his 50 years of oncology surgical practice and of the author's research achievement during his 20 years of animal cancer experimentation and clinical research. The book is divided into 38 chapters in which the author demonstrates innovative concepts of cancer therapy including a new cognition of cancer etiology and pathogenesis, new concepts and methods of cancer therapy and anti-cancer metastasis and recurrence. The author also demonstrates experimental information and analysis of clinically testified results and new ways of conquering the cancers from many aspects. The cancer existing in the human body has three forms: the two points and a line, and “eight steps” and “three stages” of carcinoma metastasis, the third field of anti-carcinoma-metastasis and recurrence treatment, three Steps of therapy of carcinoma metastasis, etc. It includes both the review and recall of traditional surgical and chemotherapy and radioactive therapy and the summary and analysis of the experimental information and clinical testifying results for XZ-C immunologic regulation and control anti-carcinoma traditional Chinese’s medicine which the author purified from the Chinese herbs. In addition, in this book the author added the scientific methods of the cancer therapy and the strategies and suggests for the overcoming the cancer development. Some part contents of this book have generated great attention in the international field of oncology. In this book the contents are creative and the ideas are new and the theories are related to the practices. There are extremely high scientific value and clinical application, which is a value reference for clinical oncologist, oncology specialists and oncology scientific researcher and the family and caregivers of the cancer patients.
Survival of patient treated surgically for synchronous single-organ metastatic
NSCLC and advanced pathologic TN stage. Lung Cancer 2012;78:234–8.
Griffioen GH, Toguri D, Dahele M, et al. Radical treatment of synchronous
Author: Raja Flores
Publisher: Elsevier Health Sciences
This issue of Thoracic Surgery Clinics is devoted to "Advanced Lung Cancer: Radical Surgical Therapy" and is edited by Dr. Raja M. Flores. Articles in this outstanding issue include: Surgical Resection of Lung Cancer in the Elderly; Extended Chest Wall Resection and Reconstruction in the Setting of Lung Cancer; The Management of Non–Small Cell Lung Cancer with Oligometastases; Lung Resection in Patients with Marginal Pulmonary Function; Surgery for Small Cell Lung Cancer; Bronchial and Arterial Sleeve Resection after Induction Therapy for Lung Cancer; Advanced Lung Cancer: Aggressive Surgical Therapy Vertebral Body Involvement; Pulmonary Resection after Pneumonectomy; Superior Vena Caval Resection in Lung Cancer; Surgical Resection of Non-Small Cell Lung Cancer with N2 Disease; Lung Transplantation for Multifocal Lung Adenocarcinoma; Extended Resections of Non-Small Cell Lung Cancers Invading the Aorta, Pulmonary Artery, Left Atrium or Esophagus: Can They Be Justified?; VATS Lobectomy after Induction Therapy; Extrapleural Pneumonectomy for Pleural Disease; Carinal Resection, and more!
something to say in favour of a flat pad being secured over the abdominal
aperture in a young child , but he opines that if the hernia persists in spite of this
treatment after the seventh year , operation for the radical cure may be , indeed is
Radical Treatment . The plastic operations which have been performed , and
which have for their object to cover the exposed mucous surface with skin , aim at
remedying only the two latter of the four main inconveniences of the deformity ...
Author: Timothy Holmes
Free radicals are involved in the pathology of many CNS disorders, like
Parkinson's disease, Alzheimer's disease, or stroke. This discovery lead to the
development of many radical scavengers for the clinical treatment of
Author: Horst Przuntek
Publisher: Springer Science & Business Media
Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.
I believe that the man studying them should have a broad knowledge of the
natural history of these tumors and a comprehensive idea of the possibilities
encompassed in the different forms of treatment, both of a radical and a
Active surveillance aims to avoid the unnecessary treatment of men with indolent
cancers while still providing timely radical treatment for those who need it. Key to
its success is therefore the ability to identify, in a timely fashion, those men who ...
Author: Laurence Klotz
Publisher: Springer Science & Business Media
Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
By adding hydrogen peroxide, the net production of hydroxyl free radicals is 1.0
mole hydroxyl radical per mole ozone. The two principal methods of disinfection
are (1) direct oxidation of compounds by aqueous ozone (O3(aq)) and (2) ...
Author: David L. Russell
Publisher: John Wiley & Sons
Category: Technology & Engineering
Practical techniques for handling industrial waste and designing treatment facilities Practical Wastewater Treatment is designed as a teaching and training tool for chemical, civil, and environmental engineers. Based on an AIChE training course, developed and taught by the author, this manual equips readers with the skills and knowledge needed to design a wastewater treatment plant and handle various types of industrial wastes. With its emphasis on design issues and practical considerations, the manual enables readers to master treatment techniques for managing a wide range of industrial wastes, including oil, blood and protein, milk, plating, refinery, and phenolic and chemical plant wastes. A key topic presented in the manual is biological modeling for designing wastewater treatment plants. The author demonstrates how these models lead to both more efficient and more economical plants. As a practical training tool, this manual contains a number of features to assist readers in tackling complex, real-world problems, including: * Examples and worked problems throughout the manual demonstrate how various treatment plants and treatment techniques work * Figures and diagrams help readers visualize and understand complex design issues * References as well as links to online resources serve as a gateway to additional information * Practical design hints, stemming from the author's extensive experience, help readers save time and avoid unwanted and expensive pitfalls * Clear and logically organized presentation has been developed and refined based on an AIChE course taught by the author in the United States, Mexico, and Venezuela Whether a novice or experienced practitioner, any engineer who deals with the treatment of industrial waste will find a myriad of practical advice and useful techniques that they can immediately apply to solve problems in wastewater treatment.
ROLE OF MEDICAL TREATMENT Early detection of CaP offers a chance for cure
. Stages 1 and 2 (Table 10.1)2 are treated by radical prostatectomy; with
radiotherapy and cryosurgery as options. Stage T3, T4, and metastatic cancer
cannot be ...
Author: Ismaila A Mungadi
Publisher: JP Medical Ltd
Urology is one of the most rapidly advancing specialties of medicine and this book is a concise guide to the medical management of urologic disorders. Divided into two sections, each chapter examines the use of drug therapy to treat different urological conditions. Section 1 covers benign urological diseases including erectile dysfunction, urinary incontinence and prostate enlargement. Section 2 covers the medical treatment of urological cancer, including renal, bladder, prostate, testicular, and Wilm’s Tumour. This concise guide also provides trainees with a quick reference to drug choice, dosing and complications. Normal values of laboratory tests of urological interest are included in the appendix. Key points Concise guide to medical management of urological disorders Covers benign conditions and urological cancers Quick reference on drug choice, dosing and complications Includes summary of normal values of laboratory tests
When the patient is first seen, a decision must be made to recommend radical
treatment, palliative treatment, or supportive care alone. Typical schedules are
shown in Table 1 .4. In general, this decision is based on two main factors: age
Author: Eduardo Bruera
Publisher: OUP Oxford
Designed to give the busy clinician immediate and practical advice on clinical problems which may arise in the management of primary and metastatic brain tumours, this text provides current guidelines for management from an authoratative team of palliative care specialists and oncologists.
There continues to be controversy about the timing of treatment for localized, for
locally advanced, and for metastatic prostate cancer. The decision for early
radical treatments in localized disease has been based on the patient's age,
Author: Jonathan Waxman
Publisher: Springer Science & Business Media
Encompasses all areas of urological cancers Combines clinical and molecular advances in one volume Only available book specific to the whole of urological malignancies Appeals equally to urologists and oncologists The well-known author has published over 250 research papers and eleven books on cancer and is also the founder of the "Prostate Cancer Charity"