Redox Genome Interactions in Health and Disease

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a ...

Author: Jürgen Fuchs

Publisher: CRC Press

ISBN: 0824756614

Category: Medical

Page: 640

View: 455

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.

Proceedings of the First International Symposium on Human Health Effects of Fruits and Vegetables

Oxidative stress in cardiovascular diseases : role of oxidized lipoproteins in
macrophage foam cell formation and atherosclerosis . pp.557– 590. In : Redox
Genome Interactions in Health and Disease . J. Fuchs , M. Podda and L. Packer (
eds . ) ...

Author: Yves Desjardins

Publisher:

ISBN:

Category: Electronic books

Page: 472

View: 920


Mitochondria

Scheffler , I. E. ( 2004 ) Mitochondrial Dysfunction in Genetic Diseases . In Fuchs ,
J. , Podda , M. , and Packer , L. , editors . Redox - Genome interactions In Health
and Disease , Marcel Dekker , New York , pp . 235–262 . 61. Wallace , D. C. ...

Author: Immo E. Scheffler

Publisher: Wiley-Liss

ISBN:

Category: Medical

Page: 462

View: 279

This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. -- Publisher.

Canadian Journal of Physiology and Pharmacology

Oxidative stress in cardiovascular disease: role of oxidized lipoproteins in
macrophage foam cell formation and athersclerosis. In Redox genome
interactions in health and disease. Edited by J. Fuchs, M. Podda, and L. Packer.
Marcel Dekker ...

Author:

Publisher:

ISBN:

Category: Pharmacology

Page:

View: 966


American Book Publishing Record

014 ' 09 The discovery of the germ : ( wenty years that transformed the way we
think about disease / John Waller . New York : Columbia ... 1 ' 05 health / editors ,
Naranjan S . Dhalla . . . [ et al . ] . ... REDOX - genome interactions in 616 . 1 ' 071
 ...

Author:

Publisher:

ISBN:

Category: American literature

Page:

View: 818


Lipoic Acid

Redox - Genome Interactions in Health and Disease , edited by Jürgen Fuchs ,
Maurizio Podda , and Lester Packer 11 . Thiamine : Catalytic Mechanisms in
Normal and Disease States , edited by Frank Jordan and Mulchand S . Patel 12 .

Author: Mulchand S. Patel

Publisher: CRC Press

ISBN:

Category: Medical

Page: 532

View: 791

The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative, single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections: · Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives. · Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression. · Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase, and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation. Contributions from leading international researchers make Lipoic Acid the most comprehensive, up-to-date account of the impact of this potentially key molecule in diminishing the damaging effects of aging and disease.

Redox active Metals in Neurological Disorders

The hemochromatosis gene affects the age of onset of sporadic Alzheimer's
disease . ... Interaction of the h63d mutation in the hemochromatosis gene with
the apolipoprotein E epsilon 4 allele modulates age at ... Ind . Health 9 : 197–214
. 30.

Author: Steven M. LeVine

Publisher:

ISBN:

Category: Medical

Page: 358

View: 663


Olives and Olive Oil in Health and Disease Prevention

A common feature underlying these complex regulatory interactions may involve
redox-sensitive nuclear transcription factors that modulate the expression of gene
products (e.g., endothelial adhesion molecules) (Crossin, 2002). NF-κB is a ...

Author: Victor R. Preedy

Publisher: Academic Press

ISBN: 9780080922201

Category: Technology & Engineering

Page: 1520

View: 403

Long used in sacred ceremonies and associated with good health, the nutritional and health promoting benefits of olives and olive oils have been proven by an ever-increasing body of science. From cardiovascular benefits to anti-microbial, anti-cancer, antioxidant activity and effects on macrophages and aptoptosis to cellular and pathophysiollogical process, olives and olive oils are proving important in many healthful ways. For example, reactive components in olive oils or olive oil by-products have now been isolated and identified. These include tyrosol, hydroxytyrosol, 3,4-dihydroxyphenyl acetic acid elenolic acid and oleuropein. Oleic acid is the main monosaturated fatty acid of olive oil. These have putative protective effects and modulate the biochemistry of a variety of cell types including those of the vascular system. Some but not all components have been characterised by their putative pharmacological properties. It is possible that usage of these aforementioned products may have beneficial application in other disease. However, in order for this cross-fertilization to take place, a comprehensive understanding of olives and olive oils is required. Finding this knowledge in a single volume provides a key resource for scientists in a variety of food an nutritional roles. Key Features: * Explores olives and olive oil from their general aspects to the detailed level of important micro-and micronutrients * Includes coverage of various methodologies for analysis to help scientists and chemists determine the most appropriate option for their own studies, including those of olive-related compounds in other foods * Relates, in a single volume resource, information for food and nutritional chemists, pharmaceutical scientists, nutritionists and dieticians * Presents information in three key categories: General aspects of olives an olive oils; Nutritional, pharmacological and metabolic properties of olives and olive oil; Specific components of olive oil and their effects on tissue and body systems

Iron Therapy with Special Emphasis on Oxidative Stress

Author: Peter Geisser

Publisher:

ISBN: 9783952166802

Category:

Page: 142

View: 358


Iron Metabolism in Health and Disease

It has been shown by ' footprinting ' that interaction of the IRE - BP with bullfrog
ferritin mRNA in vitro is confined to the ... Given that ferritin mRNAs are not the
only transcripts that contain one or more IREs and that all functions involving
gene regulation are associated with binding to ... 1990 ) , and post - translational
interconversion of pools of IRE - BP by redox reagents is a feature seen in all
species ...

Author: Jeremy H. Brock

Publisher: W B Saunders Company

ISBN: 9780702017322

Category: Ferritin

Page: 485

View: 730

An overview of human iron metabolism. This book reviews the metabolic importance of iron in evolution, the physiology and biochemistry of internal iron exchange, iron absorption and iron storage, the molecular regulation of cellular iron homeostasis and aspects of iron and disease.

Nutrition and Epigenetics

This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease ...

Author: Emily Ho

Publisher: CRC Press

ISBN: 1482203812

Category: Medical

Page: 422

View: 716

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Diet and Exercise in Cognitive Function and Neurological Diseases

... role, 2 trace elements, 2 “nutritional genomics” or “nutrigenomics,” 3 nutritional
programming DNA methylation profiling, 9 of health and disease, 7 maternal diet,
9 one-carbon units, 9 parental nutrition, 9 nutrition–gene interactions epigenetics,
... 259 plant polyphenols AMP-activated protein kinases (AMPK), 126 plasma
membrane redox system (PMRS), 125 polyphenols, 125 rate of aging, 126, 126 ...

Author: Akhlaq A. Farooqui

Publisher: John Wiley & Sons

ISBN: 1118840569

Category: Medical

Page: 384

View: 501

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Proceedings of the Society for Experimental Biology and Medicine

... oral , protein S and thrombotic disease , 200 , 285 Copolymers , T150R 1 and
T130R2 , corticotropin induction , anterior pituitary cells ... K562 cells , 200 , 522
Coronary artery disease , antioxidant interactions , health and disease , vitamin E
and redox cycle , 200 , 271 ... insulin and glucose transporter gene expression (
rat ) , 200 , 210 streptozotocin - induced , growth hormone secretion , insulin - like
 ...

Author: Society for Experimental Biology and Medicine (New York, N.Y.)

Publisher:

ISBN:

Category: Biology

Page:

View: 744

List of members in each volume.

Bio Farms for Nutraceuticals

his chapter provides an overview of diet-gene interaction and the role of dietary
factors in human health and disease. ... The cellular redox state, or balance
between oxidants and antioxidants, regulates “life-and-death” decisions of cells (
such ...

Author: Maria Teresa Giardi

Publisher: Springer Science & Business Media

ISBN: 9781441973474

Category: Medical

Page: 334

View: 451

"Bio-Farms for Nutraceuticals" can be said to have been born of the NUTRA-SNACKS project within the Sixth Framework Programme Priority on Food Quality and Safety. One objective of NUTRA -SNACK S was to improve the nutritional and eating properties of ready-to-eat products and semi-prepared foodstuffs through better monitoring of the quality and safety of raw materials and the development of innovative processes along the production chain. Another main objective of the project was the production of ready-to-eat snacks with high nutraceutic activity. Seven research institutes and three companies in six European countries were involved in this effort. The co-operation resulted in the production of food having a high content of natural metabolites with the following beneficial health effects: anticancer, antilipidemic, anticholesterol, antimicrobial, antibacterial, antifungal, antiviral, antihypertensive, anti-inflamatory and antioxidant activities.

Oxidative Stress and Redox Signalling in Parkinsons Disease

This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease.

Author: Rodrigo Franco

Publisher: Royal Society of Chemistry

ISBN: 1788011910

Category: Medical

Page: 520

View: 179

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Environmental Health Perspectives

Potential role of ultrafine particles in associations between airborne particle mass
and cardiovascular health . ... antioxidant activity , and platelet activation are
associated with urban air pollution in elderly subjects with a history of coronary
artery disease . ... Air - pollutant chemicals and oxidized lipids exhibit genome -
wide synergistic effects on endothelial cells . ... Sioulas C. 2007 Relationship
between redox activity and chemical speciation of sue - tracbonated particulate
matter .

Author:

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ISBN:

Category: Environmental health

Page:

View: 833


Chemical Abstracts

Author:

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ISBN:

Category: Chemistry

Page:

View: 383


Research Awards Index

... studies in rheumatic diseases - Interaction of IgM with complement (human)
R01AM-06097-23 Pituitary lactogenic and ... (rats) P30ES-00260-14 0039
Research in the environmental health Sciences - Distribution of inhaled Sulfur
dioxide Or ... of cholesterol in biological membranes R016M-22662-01
Flavoenzyme mechanisms-Redox and non-redox reactions ... mechanisms -
DNA-protein interactions, control of genome function R01CM-15792-10 0002
Structure and relations of ...

Author:

Publisher:

ISBN:

Category: Medicine

Page:

View: 209


Public Health Service grants and awards

... CORTICAL FUNCTION IN HUMAN DISEASE STRUCTURAL AND
FUNCTIONAL ORGANELLE INTERACTIONS CNS ... OF BACILLUS SUBTILIS
PROTEINASE GENE - PROTEIN STUDIES OF BACILLUS SUBTILIS
PROTEINASE REDOX ...

Author:

Publisher:

ISBN:

Category:

Page:

View: 133


Molecular Basis of Cardiovascular Disease

A Companion to Braunwald's Heart Disease Kenneth R. Chien, Eugene
Braunwald ... Schmidt AM , Haseu M , Popov D , et al : The receptor for advanced
glycation endproducts ( AGEs ) has a central role in vessel wall interaction and
gene ... Wenger NK , Speroff L , Packard B : Cardiovascular health and disease
in women . ... Sen CK , Packer L : Antioxidant and redox regulation of gene
transcription .

Author: Kenneth R. Chien

Publisher:

ISBN:

Category: Biología molecular

Page: 637

View: 728

Covering the molecular basis of heart disease, this text evaluates topics such as genetic mapping approaches in inherited cardiovascular disorders, and driving mechanisms in the transition from cardiac hypertrophy to heart failure.