Smad Signal Transduction

The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

Author: Peter Dijke

Publisher: Springer Science & Business Media

ISBN: 1402047096

Category: Science

Page: 472

View: 794

This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

Effects of Nerve Growth Factor on TGF Smad TGF beta Smad Signal Transduction in PC12 Cells

Author: Marion Lutz




Page: 286

View: 702

Signal Transduction in the Cardiovascular System in Health and Disease

Given the widely accepted role of c-Ski as a TGF-β1 signal repressor, it may
preferentially interact with Smad3 and Smad4 to ablate R-Smad function in heart,
as has been reported using COS-1 and Mv1Lu cells (Ueki and Hayman 2003).

Author: Ashok K. Srivastava

Publisher: Springer Science & Business Media

ISBN: 0387095527

Category: Medical

Page: 424

View: 465

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Vitamin D in Chronic Kidney Disease

... renal interstitial fibroblasts [59]. The TGFβ superfamily comprises pleiotropic
cytokines that regulate SMAD and non-SMAD signaling. TGFβ–SMAD signal
transduction is known to be involved in tissue fibrosis, including renal fibrosis.

Author: Pablo A. Ureña Torres

Publisher: Springer

ISBN: 3319325078

Category: Medical

Page: 574

View: 588

Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.

Medical Cell Biology

The type I receptor then transduces the TGF-β signal by phosphorylating
downstream signal transducer molecules. ... Alternatively, the BMP signal can be
transmitted via the Smad signal transduction pathway (see Figs. 8–6 and 8–7).

Author: Steven R Goodman

Publisher: Academic Press

ISBN: 9780080919317

Category: Science

Page: 336

View: 379

Medical Cell Biology, Third Edition, focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. With its National Board-type questions, this book is specifically designed to prepare students for this exam. The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease. This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology. 60% New Material! New Topics include: Apoptosis and cell dealth from a neural perspective Signal transduction as it relates to normal and abnormal heart function Cell cycle and cell division related to cancer biology All new clinical cases Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students

Signal Transduction

Smads have multiple roles in signal transduction The Smad proteins have two
regions of homology, MH1 and MH2 (Mad homology), at the N- and C-terminals.
The nine members of this family have different functions which are controlled ...

Author: Bastien D. Gomperts

Publisher: Gulf Professional Publishing

ISBN: 0080541186

Category: Science

Page: 420

View: 491

Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine Extensive conceptual colour artwork assists with the comprehension of key topics Extensive referencing provides an invaluable link to the core and historical literature Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Dail and Hammar s Pulmonary Pathology

Signal transduction by the JNK group of MAP kinases. ... structure, regulation and
function of the Janus kinases (JAKs) and the signal transducers and activators of
transcription (STATs). ... TGF-beta and the Smad signal transduction pathway.

Author: Joseph F. Tomashefski

Publisher: Springer Science & Business Media

ISBN: 9780387721149

Category: Medical

Page: 869

View: 157

Dail and Hammar’s Pulmonary Pathology has established itself as the definitive reference in the field. This third edition is now a two-volume, full color text. The new editorial board has continued to build upon the excellence previously achieved by reorganizing, expanding and substantially revising the text. This authoritative reference work has been updated to cover newly recognized entities and the latest advances in molecular diagnostic techniques. Abundantly illustrated with more than 2000 full color illustrations, this outstanding contribution to pathology literature is a must-have for the library of every surgical and pulmonary pathologist.

Transforming Growth Factor Beta in Cancer Therapy Volume II

In: Smad signal transduction: Smads in proliferation, differentiation and disease.
ten Dijke P and Heldin C-H, eds Springer Verlag, 2006, pp 443—459. 2. Akhurst
RJ, Derynck R. TGF-beta signaling in cancer-a double-edged sword. Trends Cell

Author: Sonia B. Jakowlew

Publisher: Springer Science & Business Media

ISBN: 1597452939

Category: Medical

Page: 786

View: 827

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Signal Transduction in Cancer Metastasis

There are several transcriptional factors such as AP1, Ets, Smad and Snail
regulating a lot of genes relevant to ... Comprehensive understanding of the ROS
-triggered signaling transduction, transcriptional activation and regulation of gene

Author: Wen-Sheng Wu

Publisher: Springer Science & Business Media

ISBN: 9789048195220

Category: Medical

Page: 288

View: 218

This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Targeted Interference with Signal Transduction Events

Signaling. Pathway. in. Klaus Podar, Noopur Raje, and Kenneth C. Anderson
Recent Results in Cancer Research, Vol. 172 © Springer-Verlag Berlin ... 6.1
TGF−β- signaling via Smad-dependent and Smad-independent pathways. TGF
−β ...

Author: B. Groner

Publisher: Springer Science & Business Media

ISBN: 3540312099

Category: Medical

Page: 188

View: 245

This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?

Transforming Growth Factor Beta in Cancer Therapy Volume I

Several recent studies have indicated that Smad 2/3 are the R-Smad proteins for
myostatin signaling (42,43) and that ... We have examined the R-Smad
components involved in the myostatin signal transduction by investigating the
roles of ...

Author: Sonia B. Jakowlew

Publisher: Springer Science & Business Media

ISBN: 1597452920

Category: Medical

Page: 735

View: 797

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Biochemistry of Signal Transduction and Regulation

Author: Gerhard Krauss

Publisher: Wiley-VCH


Category: Science

Page: 626

View: 144

The molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis is made transparent for those with a basic knowledge in biochemistry or molecular biology. This title has been thoroughly updated to keep pace with the rapid progress in signal transduction research.

Cardiovascular Genetics and Genomics in Clinical Practice

Once activated, this receptor complex stimulates the R-Smad family of signal
transduction proteins (Smad-1, 2, 3, 5, or 8) (25). These signal proteins recruit the
nuclear chaperone Smad-4 for travel into the nucleus and interaction with
nuclear ...

Author: Donna K. Arnett, PhD

Publisher: Demos Medical Publishing

ISBN: 1617051780

Category: Medical

Page: 246

View: 620

Weighted Numerical Score: 100 - 5 Stars! This is a systematic guide to cardiovascular genetics and genomics from basic concepts to clinical application. It organizes a large volume of information from an active area of research, which holds promise for future discovery. --Doody's Reviews Cardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand "primer" of basic scientific concepts regarding cardiovascular genetics and genomics followed by state-of-the-art research and applications for treatment of cardiovascular disorders. Expert clinicians and researchers describe illustrative cases for each topic along with detailed discussions of current scientific understanding and its application in current disease management and treatment. Summaries, key teaching points, and illustrations are highlighted to facilitate quick recall and review. The book will be useful for cardiovascular clinicians in training, board preparation, or as a review for those already in clinical practice. Cardiovascular Genetics and Genomics in Clinical Practice features: Clinical case scenarios to illuminate the basic concepts of cardiovascular genetics and genomics as they are used in daily practice Explanation of fundamental concepts as a foundation for more in-depth understanding Detailed discussions of current scientific knowledge and clinical management The expertise of renowned clinician-scientists in the field Real practical insight for practice

Endocrinology Adult and Pediatric E Book

A FoxL in the Smad house: Activin regulation of FSH. Trends Endocrinol Metab.
2011;21: 562–568. Tran S ... Smad Signal Transduction: Smads in Proliferation,
Differentiation and Disease Springer Netherlands. 2007:277–293. 184. 185. 186.

Author: J. Larry Jameson

Publisher: Elsevier Health Sciences

ISBN: 032332195X

Category: Medical

Page: 2700

View: 438

Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.

Rheumatology E Book

(αvβ3, αvβ5, αvβ6, and αvβ8) Intracellular TGF-β signaling involves both canonic
Smad and Smadindependentsignaling cascades. Canonic TGF-β signal
transduction involves sequential phosphorylation of the type I TGF-β receptor ...

Author: Marc C. Hochberg

Publisher: Elsevier Health Sciences

ISBN: 0702063037

Category: Medical

Page: 2112

View: 652

Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.

Invertebrate Cytokines and the Phylogeny of Immunity

6.2 Smad Anchor for Receptor Activation Efficient signaling by transmembrane
receptors frequently requires pre-assem- bly of signal transduction components
through the use of scaffolding proteins. The Smad anchor for receptor activation ...

Author: Alain Beschin

Publisher: Springer Science & Business Media

ISBN: 9783540404071

Category: Science

Page: 184

View: 790

Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.

Advances in Cancer Research

It remains to be seen whether inhibition of Smad signaling might lead to
enhanced TGF-β signaling through MAP kinase pathways, ... in ovarian cancer, it
is tempting to speculate that, analogous to the role of TGIF in TGF-β signal
transduction ...


Publisher: Elsevier

ISBN: 9780080522289

Category: Science

Page: 261

View: 381

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including suppressor and oncogenic roles of TGF-b and its signaling pathways in tumorigenesis, hereditary diffuse gastric disease, the role of heparan sulfate proteoglycans in cell signaling and cancer, V-gene mutations in B-cell-derived human malignancy, MHC antigens and tumor escape from immune surveillance, the role of selection in progressive neoplastic transformation, and the genomic stability, neuronal development, and cancer cross paths of ATM. Suppressor and Oncogenic Roles of TGF-aand Its Signaling Pathways in Tumorigenesis Hereditary Diffuse Gastric Disease Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer The Occurrence and Significance of V-Vene Mutations in B Cell-Derived Human Malignancy MHC Antigens and Tumor Escape from Immune Surveillance Foundations in Cancer Research: The Role of Selection in Progressive Neoplastic Transformation ATM: Genomic Stability, Neuronal Development, and Cancer Cross Paths

Abeloff s Clinical Oncology E Book

Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9
teratocarcinoma cells via pathways that require Galpha(q) and ... Itoh S, ten Dijke
P. Negative regulation of TGFbeta receptor/Smad signal transduction.

Author: John E. Niederhuber

Publisher: Elsevier Health Sciences

ISBN: 1455728810

Category: Medical

Page: 2224

View: 370

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

By Participating in the TGF Smad Signaling Pathway LRP12 Regulates the Tumorigenicity of Human Fibrosarcoma derived Cell Line SHAC

Smad transcription factors . Genes Dev 19 ( 23 ) : 2783-810 . Massague , J. and
Wotton , D. ( 2000 ) . Transcriptional control by the TGF - beta / Smad signaling
system . Embo J 19 ( 8 ) ... TGF - beta and the Smad signal transduction pathway

Author: Jie Zhang



Category: Antioncogenes

Page: 434

View: 116

Protein Modules in Cellular Signalling

Moreover, Smad signalling is not only determined b> the actuation of the II.l'l1
family receptors bul also ma> be regulated ... Key Words: Smads, TGF-p, signal
transduction. signalling cross-talk Abbreviations: AP-1. activating protein- 1; ATF-

Author: Ludwig Heilmeyer

Publisher: IOS Press

ISBN: 9781586031800

Category: Science

Page: 396

View: 186

Dynamic stability of cells is a function of co-ordination and counterbalance between intracellular signalling events. Therefore, the knowledge of those molecules which form signalling cascades or signalling modules is of prime importance in understanding living processes. Signalling proteins, the component members of different cascades, are the focus of intense interest. Protein phosphorylation dephosphorylation is the prevalent mechanism by which signalling molecules transduce their signals.