Viral Superantigens

Chapter 2 Viral Superantigen - Mediated Negative Selection Chihiro Morishima
and Ann M. Pullen CONTENTS 13 15 16 17 17 1 Introduction . ... A Model System
for Negative Selection Using Viral Superantigens Encoded by Mtvl and Mtvá ..

Author: Kyuhei Tomonari

Publisher: CRC Press

ISBN: 9780849376887

Category: Medical

Page: 276

View: 784

Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.

Cumulated Index Medicus

not Characterization of anergy to the superantigen IMMUNOLOGY enterotoxin A
in T - cell receptor V beta 3 transgenic mice . ... Cell Immunol 1993 Dec ; ( Viral
superantigens ] Yoshikai Y. Uirusu 1993 Jun ; 152 ( 2 ) : 348-57 Human T - cell ...

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Category: Medicine

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Annual Scientific Report

TCR Va usage clearly influenced viral superantigen reactivity . ... T Cell
Recognition of Retroviral Superantigens in the Mouse It is important to gain an
understanding of the presentation and recognition of retroviral superantigens
because ...

Author: Howard Hughes Medical Institute

Publisher:

ISBN:

Category: Cytology

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Current Opinion in Infectious Diseases

GOLOB KJ , PALMER E : Divergent Viral Superantigens Delete Vbeta5 +
Lymphocytes - T . Proc Natl Acad Sci USA ... DUDLEY JP , ROSS SR :
Transgenic Mouse Mammary Tumor Virus Superantigen Expression Prevents
Viral Infection .

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Category: Communicable diseases

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Bacterial Superantigens

There is , however , mounting evidence that indicates that other members of the S
. aureus enterotoxin family , as well as the currently known viral superantigens ,
will interact with class II MHC molecules in ways that differ significantly from the ...

Author: Jacques Thibodeau

Publisher: R G Landes Company

ISBN: 9781570592645

Category: Science

Page: 241

View: 850


Annual Review of Cell Biology

The inclusion of the lymphotropic viruses , EBV , MAIDS , and HIV on this list is
particularly interesting given the evidence , discussed below , that the viral
superantigens may serve to provide activated lymphocytes in which invading
viruses ...

Author: George E. Palade

Publisher:

ISBN: 9780824331092

Category: Science

Page: 671

View: 837

Among the topics presented in 19 contributions: cell-mediated events that control blood coagulation, spectrin-based membrane structure and micron-scale organization of the plasma membrane, superantigens, biology of animal lectins, signal transduction in guard cells. Annotation copyright by Book News, Inc., Portland, OR

The Journal of Immunology

META - controlled env - initiated transcripts encoding superantigens of murine
Mtv29 and Mtv7 and their possible role in B cell lymphomagenesis . ... Influence
of MTV superantigen on B cell lymphoma in SJL / ) mice . In Viral Superantigens .

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Category: Immunology

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View: 577


Immunobiology 5 the Immune System in Health and Disease

5 - 15 Many T cells respond to superantigens . Toxic Shock Syndrome Bacterial
superantigen eg SE , TSST - 1 Viral superantigen Superantigens are a distinct
class of antigens that stimulate a primary T - cell response similar in magnitude to
a ...

Author: Charles Janeway

Publisher: Garland Science

ISBN: 9780815336426

Category: Medical

Page: 732

View: 742

Designed for providers who work with judicial clients, the Providers Guide presents effective cognitive-behavioral treatment approaches. The Second Edition of this bestseller unveils a state-of-the-art approach for effectively preventing criminal recidivism and substance abuse relapse within community based and correctional settings. The core of the SSC program is a positive relationship between provider and client. Summary of results survey from the first edition of SSC 95% of the providers rated the components of SSC to be adequate to very adequate in meeting the treatment needs of judicial clients Over 90% of providers rated clients as having a moderate to very high involvement in homework and reading 95% of the clients rates as very high their satisfaction of SSC delivery, the provider's response to client needs and clients' comfort with providers Around 80% of clients reported their cognitive and behavioral control over AOD use and criminal conduct had improved during SSC The accompanying Participant's Workbook to the SSC is written to engage clients and encourage active participation in treatment and responsible living: Phase I: Challenge to Change: Building Knowledge and Skills for Responsible Living Phase II: Commitment to Change: Strengthening Skills for Self-Improvement, Change, and Responsible Living Phase III: Taking Ownership of Change: Lifestyle Balance and Healthy Living

Vaccines Against Virally Induced Cancers

The role of superantigens in the immunobiology of retroviruses Brigitte T. Huber,
Ulrich Beutner and Meena ... Murine mammary tumour viruses (MMTVs) are
retroviruses that encode superantigens capable of stimulating T cells via ...

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

ISBN: 047051468X

Category: Medical

Page: 292

View: 735

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tumors and discuss the means by which they can be improved.

Viral Vectors

Further refinement of these methods to permit precise gene replacement
beginning with the initiation codon of a viral ... in a study of HVS orf14 , which
encodes a viral superantigen related to mouse mammary tumor virus
superantigens ( 31 ) .

Author: Angel Cid-Arregui

Publisher: Eaton Publishing Company

ISBN:

Category: Science

Page: 641

View: 467


Superantigen Protocols

Expression of Viral Superantigens Mouse mammary tumor viral superantigens (
vSAgs) are produced by germline-encoded proviruses and infectious viruses (for
reviews see refs. 1,2). Like other superantigens, they interact with class II major ...

Author: Teresa Krakauer

Publisher: Springer Science & Business Media

ISBN: 1592593674

Category: Medical

Page: 260

View: 925

Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors to those for the analysis of their immunological and biological effects, including methods for using BIOcore to determine binding kinetics and establishing various lymphocyte cell culture systems. There are also accounts of such methods as the RNase protection assay, cytokine ELISA, FACS analysis, and cytokine production at the single cell level..

Effects of Microbes on the Immune System

A number of bacterial and viral superantigens have been identified and may play
a role in the pathogenesis of various human diseases . This chapter focuses
primarily on staphylococcal superantigens . DESCRIPTION OF
SUPERANTIGENS ...

Author: Madeleine W. Cunningham

Publisher:

ISBN:

Category: Medical

Page: 662

View: 423

Written by the foremost leaders in immunologic research, this volume is a definitive text on the ways in which bacteria, viruses, parasites, and fungi affect the immune response in the host. The book synthesizes recent discoveries on the various mechanisms by which microbes subvert the immune response and on the role of these immunologic mechanisms in the pathogenesis of infectious diseases. Each chapter examines a particular group of infectious pathogens and focuses on the immunobiology of the disease. A separate section explores potential vaccines for mucosal or conventional delivery.

Survival of Parasites Microbes and Tumours

... of bacterial superantigens Role in the pathogenesis of bacterial infections
Potential advantages for the bacteria Viral superantigens Mouse mammary
tumour virus superantigens Different forms of MMTV Identification of MMTV
superantigens ...

Author: M. J. Doenhoff

Publisher: Cambridge University Press

ISBN: 9780521645829

Category: Medical

Page: 184

View: 687

The papers in this volume draw attention to both new and recent information on the mechanisms employed by infectious pathogens to underpin their survival in the immunocompetent host and to facilitate their transmission between hosts.

Proceedings of the National Academy of Sciences of the United States of America

Negative - acting factor and superantigen are separable activities of the mouse
mammary tumor virus long terminal repeat ( transcriptional down regulation /
mixed lymphocyte reaction / novel promoter ) STEFAN WINTERSPERGER * ,
BRIAN ...

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Category: Electronic journals

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Immunological and Molecular Diagnosis of Infectious Disease

SEARCHING FOR SUPERANTIGENS P.M. Schlievert Department of
Microbiology Medical School , University of Minnesota Minneapolis , Minnesota
55455 ABSTRACT Superantigens comprise a large group of viral and bacterial
proteins that ...

Author: Carel J. van Oss

Publisher: CRC Press

ISBN: 9780824700928

Category: Medical

Page: 328

View: 779

Written by world-renowned experts, this book addresses immunological and molecular methodologies of diagnosis as well as clinical aspects of diseases. It book discusses DNA and RNA amplification methods, explains ELISA approaches, and introduces rapid diagnosis techniques, biosensors, and flow cytometry. The book examines bacterial and parasitic infections, including M. tuberculosis, Borrelia burgdorferi, Streptococcus pyogenes, chlamydia and schistosomes, and describe viral infections such as hantaviruses, hepatitis C., cytomegalovirus, herpes virus, and HIV. It also covers syndromes with infections origins, including prions, chronic fatigue syndrome, and superantigens, and much more.

Annual Scientific Report

MacDonald HR . Mechanisms of central and peripheral T cell tolerance : the
superantigen paradigm . ... Acha - Orbea H . Bacterial and viral superantigens .
Roles in ... Exogenous and endogenous mouse mammary tumor virus
superantigens .

Author: Ludwig Institute for Cancer Research

Publisher:

ISBN:

Category: Neoplasms

Page:

View: 351


Structural Features Involved in the Biological Activities of Staphylococcal Enterotoxin A

Most identified superantigens are produced by bacteria or viruses , although
there is preliminary evidence for a superantigen produced by a nematode ( 166 )
, superantigen activity from a plant lectin ( 70 ) and evidence for a superantigen ...

Author: Mark Andrew Hoffman

Publisher:

ISBN:

Category:

Page: 396

View: 710


Scientific Report

that the superantigen is expressed on the cell surface of B cells that express
MHC class II molecules , as expected ... of our colleagues S . Webb and J .
Sprent that CD8 T cells strongly induce T - cell responses to viral superantigens
in vivo .

Author: Scripps Research Institute

Publisher:

ISBN:

Category: Medicine

Page:

View: 254


The Cumulative Book Index

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Category: American literature

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A world list of books in the English language.

European Conference on Toxic Shock Syndrome

Properties of pyrogenic toxin superantigens Many superantigens have been
described ( 1 ) . The first to be recognized was murine mammary tumour virus .
Other viral superantigens include rabies , Epstein - Barr and human
immunodeficiency ...

Author: J. P. Arbuthnott

Publisher:

ISBN:

Category: Septic shock syndrome

Page: 216

View: 930